Measles Virus Hemagglutinin Protein Epitopes: The Basis of Antigenic Stability
نویسندگان
چکیده
منابع مشابه
Measles Virus Hemagglutinin Protein Epitopes: The Basis of Antigenic Stability
Globally eliminating measles using available vaccines is biologically feasible because the measles virus (MV) hemagglutinin (H) protein is antigenically stable. The H protein is responsible for receptor binding, and is the main target of neutralizing antibodies. The immunodominant epitope, known as the hemagglutinating and noose epitope, is located near the receptor-binding site (RBS). The RBS ...
متن کاملErratum: Tahara, M., et al. Measles Virus Hemagglutinin Protein Epitopes: The Basis of Antigenic Stability. Viruses 2016, 8, 216
The authors wish to make the following change to their paper [1].[...].
متن کاملAntigenic determinants of measles virus hemagglutinin associated with neurovirulence.
The biological activity of monoclonal antibodies specific for the hemagglutinin protein of measles virus strain CAM recognizing six epitope groups according to their binding properties to measles virus strain CAM/R401 was investigated in vivo in our rat model of measles encephalitis. When injected intraperitoneally into measles virus-infected suckling rats, some monoclonal antibodies modified t...
متن کاملPurification and Some Antigenic Properties of Measles Virus Hemagglutinin.
PeriesとChanyら (1960) が麻 疹 ウイル スが, ba boon erythrocytesを 凝集す る ことを初めて報告 して以来 この ウイルス の赤血球凝集素 (HAnin) の研究がかな り 進 められ てきた. Funahashiら (1963) は猿血球 の中で も種 に よ りウイ ル スに対す る感受性 にかな り差がみ られ, なかで もgreen monkeyとrhesus monkeyの 血球 は感受性 が高 く個 体 差 も少 ないが, cynomolgus monkeyの 血球は感受性 は 一 般 に低 く個体差 が多い こと , 及び麻疹 ウイル スをエー テルTween 80処 理す る と赤血球凝集価 (HA価) が上昇 し, この もの を庶糖濃度勾配又 はCsCl濃 度勾配平衡遠 心 法 な どによ り超遠心 する とHA nin...
متن کاملFunctional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein.
Effective vaccination programs have dramatically reduced the number of measles-related deaths globally. Although all the available data suggest that measles eradication is biologically feasible, a structural and biochemical basis for the single serotype nature of measles virus (MV) remains to be provided. The hemagglutinin (H) protein, which binds to two discrete proteinaceous receptors, is the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Viruses
سال: 2016
ISSN: 1999-4915
DOI: 10.3390/v8080216